Travelzoo research thousands of travel deals each week and selects the Top 20. You can sign up for their free Top 20 weekly travel deal email.
You can search on Expedia for (hopefully) the best deal on airline tickets. They also have a search for hotels and rental cars.
Travelocity is similar to Expedia. You can search for airline fares, hotels, and rental cars.
You can get some pretty good airline ticket prices on Priceline. It is helpful if you use expedia.com first to find out the lowest price available between the
cities you are interested in. Then you can decide how much to bid on priceline. Sometimes you can get a equal or better price from a more convenient city.
Hotwire allows you to search for hotels and rental cars. They will show you the best deals that they have available, without showing you the name of the hotel
or rental car company. After you choose to buy, then you find out what hotel you will be staying at or what rental car company you will be using.
FlightView allows you to check the status of a flight that is currently in the air.
After you have found the best deal for a airline flight, now you want to find the best seat. Seat Guru has diagrams of the plane layouts for the various
airlines. Take note first (from your itinerary) what type of aircraft you will be flying on, then use Seat Guru to find the best seats.